Obesity is one of the major healthcare challenges worldwide and elucidation of genetic susceptibility variants has been exploded during last years. Common variants have been confirmed for many different genomic loci via genome-wide association studies and meta-analyses. Still the effect sizes are low and represent only part of the overall heritability of polygenic obesity. Our research group is interested in (i) genetic variation underlying human eating behavior and (ii) in epigenetic mechanisms in different human adipose tissue depots. We hope to better understand the “missing heritability” of obesity.
The main team of our group is based at University of Oslo and Akershus University Hospital in Norway (UiO). Another team is working at the University of Leipzig, IFB AdiposityDiseases, Germany (Uni Leipzig).
functional genetics of obesity 